2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W042714
    BnO-PEG5-OH 57671-28-0 98.55%
    BnO-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    BnO-PEG5-OH
  • HY-130373
    Propargyl-PEG9-amine 2093153-98-9
    Propargyl-PEG9-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG9-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG9-amine
  • HY-141372
    Bromo-PEG3-CH2-Boc 2100306-71-4 98.0%
    Bromo-PEG3-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG3-CH2-Boc
  • HY-140819
    Bromo-PEG1-C2-azide 1144106-65-9 99.45%
    Bromo-PEG1-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG1-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG1-C2-azide
  • HY-140727
    Boc-NH-PEG-amine (MW 5000) ≥98.0%
    Boc-NH-PEG-amine (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG-amine (MW 5000)
  • HY-140234
    Boc-NH-PEG11-NH2 1233234-77-9 99.78%
    Boc-NH-PEG11-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG11-NH2
  • HY-42359
    N-(4-Carboxycyclohexylmethyl)maleimide 64987-82-2
    N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(4-Carboxycyclohexylmethyl)maleimide
  • HY-140225
    m-PEG5-NH2 5498-83-9 99.02%
    m-PEG5-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG5-NH2
  • HY-140828
    m-PEG4-azide 606130-90-9 98.0%
    m-PEG4-azide (13-Azido-2,5,8,11-tetraoxatridecane) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG4-azide
  • HY-140534
    4-(N-Boc-amino)-1,6-heptanedioic acid 848242-88-6 98.0%
    4-(N-Boc-amino)-1,6-heptanedioic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    4-(N-Boc-amino)-1,6-heptanedioic acid
  • HY-132101
    Amino-PEG7-t-butyl ester 2428400-07-9 98.0%
    Amino-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Amino-PEG7-t-butyl ester is a PEG reagent containing an amino NH2 group with a t-butyl protected carboxyl group (Boc). Amino-PEG7-t-butyl ester can be used in drug delivery research.
    Amino-PEG7-t-butyl ester
  • HY-140026
    Propargyl-PEG1-Boc 488150-84-1
    Propargyl-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG1-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG1-Boc
  • HY-133470
    Fmoc-NH-PEG4-alcohol 868594-41-6 99.18%
    Fmoc-NH-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG4-alcohol
  • HY-400145
    mPEG45-Epoxide 40349-67-5
    mPEG45-Epoxide is a PEG derivative containing polyether units. mPEG45-Epoxide can be used to synthesize PROTAC molecules.
    mPEG45-Epoxide
  • HY-133456
    Biotin-PEG2-aldehyde
    Biotin-PEG2-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG2-aldehyde
  • HY-W101723
    Boc-12-Ado-OH 18934-81-1
    Boc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    Boc-12-Ado-OH
  • HY-W097128
    Fmoc-12-aminododecanoic acid 128917-74-8
    Fmoc-12-aminododecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
    Fmoc-12-aminododecanoic acid
  • HY-140516
    NH-bis(PEG4-acid) 2055041-59-1
    NH-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH-bis(PEG4-acid)
  • HY-140204
    Amino-PEG9-alcohol 15332-95-3 98.0%
    Amino-PEG9-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG9-alcohol
  • HY-130163
    Bromo-PEG1-CH2COOH 1135131-50-8
    Bromo-PEG1-CH2COOH is a PROTAC linker can be used in the synthesis of PROTACs.
    Bromo-PEG1-CH2COOH
PROTAC Linkers Isoform Comparison

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